On 5/21/12, the Patient Centered Outcomes Research Institute (PCORI) Board of Governors adopted a final version of its “National Priorities for Research and Research Agenda” based on input received during a public comment period. The five national priorities are assessment of options for prevention, diagnosis, and treatment; improving health care systems; communication and dissemination of research; addressing disparities; and accelerating patient-centered outcomes research. The PCORI will award $120 million this year for innovative comparative effectiveness research projects that effectively address the national priorities. An online application system for PCORI funding is expected to open on 6/1/12. Detailed explanations of the national priorities are available on the AOA comparative effectiveness research webpage.